QSAR investigation on benzimidazole derivatives in Trichomonosis’ disease
نویسندگان
چکیده
منابع مشابه
Application of QSAR models in analysis of antibacterial activity of some benzimidazole derivatives against Sarcina lutea
In the present study, a quantitative structure activity relationship (QSAR) has been carried out on a series of 2-methyl and 2-aminobenzimidazole derivatives to identify the lipophilicity requirements for their inhibitory activity against bacteria Sarcina lutea. The tested compounds displayed in vitro antibacterial activity and minimum inhibitory concentration (MIC) was determined for all compo...
متن کامل2D QSAR Study of Substituted 2-Phenyl- Benzimidazole Derivatives as Potent Anti Allergic Agents
A set of forty one substituted-2-phenyl-benzimidazole derivatives with anti-allergic activity was subjected to the two dimensional quantitative structure activity relationships studies using V life molecular design suite 3.5. Drug Designing module contain various combinations of thermodynamic, electronic, topological and spatial descriptors.Substituted-2-phenyl-benzimidazole was taken as the le...
متن کاملG-QSAR of Novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H- benzimidazole Derivatives
In the present work, we have applied group quantitative structure–activity relationships (G-QSAR) for exploring the relationship between the structures of a new emerging family of 2-{[2-(1Himidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives and their antiprotozoal activities. We have developed descriptive models, in order to aid in further optimization and development of newer antiprotoz...
متن کاملAn Insight into Antimicrobial Activity Substituted Benzimidazole Derivatives through QSAR Studies
Over the past few decades, the problems posed by multi-drug resistant microorganisms have reached an alarming level in many countries around the world [1]. This has led to a serious challenge to the medical community; hence, the development of new effective antimicrobial agents is an important goal. In pursuit of this goal, our research efforts are focused on the development of novel structural...
متن کاملEffects of Benzimidazole derivatives on digestive system and cardiovascular system
One of the goals of medicinal chemistry research and drug discovery is to provide a rationalbasis for the design of new medicinal agents. Organic compounds and their reactions have beenutilized by people since antiquity. Due to the increasing demand for bioactive molecules, organicchemists are increasingly required to synthesize new compounds of biological interest. AsBenzimidazoles are very us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JOURNAL OF ADVANCES IN BIOTECHNOLOGY
سال: 2014
ISSN: 2348-6201
DOI: 10.24297/jbt.v4i3.4998